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In low oxygen situations (hypoxia, ischaemia) lactate increases several-fold as its conversion from pyruvate in the lactate dehydrogenase reaction is essential to regenerate NADH needed to maintain glycolysis [59]

doi: 10.1155/2021/6657434 17 PisoschiAMPopA

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Furthermore, increased ACE2 expression in alveolar type II pneumocytes and alveolar macrophages of individuals with severe SARS-CoV-2 disease (ARDS with diffuse alveolar damage) requiring mechanical ventilation (Baker et al., 2021) favors a concomitant increase in oxidative stress in those individuals